The variants rs2451303 (p-value = 8.0 x 10−09) and rs6704760 (p-value = 4.50 x 10−08) were associated with LDL and mapped to the intergenic regions between NT51B and RDH14, MYCN and MYCNOS, and associated with cardiovascular diseases and neoplasm, respectively, Fig. 2. The gene discussed is MYCNOS; the disease is cardiovascular disorder.