To explore potential regulators of resistance to EGFR-TKIs in GBM, we integrated multiple layers of genomic datasets and identified six potential regulators (CDK6, GBP1, TRIP13, ERBB3, NTN4, MYH14) of intrinsic EGFR-TKIs resistance in GBM (Fig. 4A). Here, CDK6 is linked to glioblastoma.