Punicalagin prevents cardiomyopathy caused by diabetes by regulating the STAT3-PTP1B pathway, thereby promoting mitochondrial fusion mediated by Opa1.301 Activating the κ-opioid receptor is another way to promote the fusion of mitochondria through the OPA1-STAT3 pathway, which improves cardiac adaptation to IRI.302 Moreover, paeonol is a compound that enhances mitochondrial fusion mediated by Opa1 through activation of the STAT3-CK2α pathway in cardiomyopathy due to diabetes.230. Here, OPA1 is linked to diabetes mellitus.