Metastatic breast cancer cells exhibit an increase in mitochondrial fragmentation as a result of their elevated levels of active Drp1 and reduced MFN1 expression.85 Mitochondria elongation or clustering can greatly reduce the metastasis potential in cancerous breast cells, which can be caused by either Drp1 deficiency or MFN1 overexpression. Here, MFN1 is linked to breast carcinoma.