In particular, P110 has been found to diminish division of mitochondria and necrosis in neurons derived from patients with HD and PD.278,289 Dynasore is discovered from a screening of 16,000 small molecules and is the initial inhibitor of mitochondrial fission.279 It does not exhibit selectivity in inhibiting mitochondrial fission proteins, but affects the GTPase activities of Drp1 and Dynamin 1/2 in vitro.279 Studies have demonstrated that Dynasore attenuates cardiac disease and reduces neuronal damage caused by degenerative diseases via inhibiting excessive mitochondrial division.290,291. Here, DNM1L is linked to Huntington disease.