The function of CCBE1 involves inhibiting fission of mitochondria by impeding the localization of Drp1 to mitochondria by preventing phosphorylation of Drp1 at Ser616.240 In cervical carcinoma Hela cells, MFN2 inhibits proliferation and cell-cycle by inhibiting the expression of key proteins, including NF-κB p65, Myc, and mTOR, and by suppressing Ras protein activity.241. The gene discussed is DNM1L; the disease is cervical carcinoma.