DNM1L and Hyperglycemia: Furthermore, inhibition of Drp1 using genetic and pharmacological approaches effectively mitigate C2C12 cells’ mitochondrial depolarization, fragmentation, and insulin resistance as a result of PA-induced mitochondrial fragmentation, suggesting a potential therapeutic strategy for managing these detrimental effects.148 Besides, hyperglycemia during gestational diabetes mellitus poses a threat to the functioning of placental tissue.