Diabetes development is closely associated with impaired function of pancreatic β-cells, which can be triggered by various factors, including ER stress.197 The expression of Drp-1 significantly enhance apoptosis induced by ER stress in the Drp1 WT activated β-cell line, as opposed to Drp1 K38A (a dominant negative mutant of Drp1) inducible β-cell line.198 Rhein, a compound derived from rhubarb and belonging to the anthraquinone family, displays potential in ameliorating glucose metabolism disorders in mice with diabetes. Here, DNM1L is linked to glucose metabolism disease.