MFN2 and hepatocellular carcinoma: Furthermore, compared to normal gastric mucosal tissue, MFN2 expression on gastric cancer cells is downregulated, its level negatively correlates to tumor growth, suggesting a potential anti-tumor function for MFN2.237 A higher level of MFN2 appears to restrict gastric cancer cell reproduction in vitro.238 The expression of FUN14 domain-containing 2 (FUNDC2) is increased in HCC at the transcriptional level.