Down-regulating Drp1 decreases invasion and proliferation of cells and inhibits the formation of pseudopodias and microvillis.314 Blocking Drp1 leads to compromised mitochondrial autophagy and augmented apoptosis of HCC cells during hypoxia, leading to decreased membrane potential of mitochondria as well as the release of Cyt C and apoptosis-inducing factor. This evidence concerns the gene DNM1L and hepatocellular carcinoma.