However, inhibiting fragmentation of mitochondria improves mitochondrial ATP synthesis and the tumor-fighting ability of NK cells.265 In triple negative breast cancer (TNBCs), ELK3 (E26 transformation-specific transcription factor ELK3)-dependent mitochondrial fission/fusion status is a main determinant of NK cell-mediated immune responses. Here, ELK3 is linked to triple-negative breast carcinoma.