Omentin1, a newly identified adipokine, has been shown to safeguard against HF induced by myocardial ischemia.224 In mice with HF, administering omentin1 enhances mitochondrial fusion while decreasing mitochondrial fission, with an upregulation of Opa1 and MFN2, whereas a decrease in Drp1(Ser616).224 Doxycycline (DOX) exerts protective effects in animal models of HF. Here, OPA1 is linked to hydrops fetalis.