Reduction of Rab32 levels decreases the migration and invasion potential in GBM cells.242 Mechanisms underlying Rab32 promoting GBM aggressiveness involves the ERK/Drp1 pathway, i.e., Rab32 facilitates the transport of Drp1 into mitochondria, where it recruits ERK1/2 to phosphorylate the Ser616 region of Drp1.242. The gene discussed is MAPK3; the disease is glioblastoma.