Paeonol, a bioactive compound with potential pharmacological benefits in protecting the heart and mitochondria, promotes the fusion of mitochondrial mediated by Opa1, alleviates the accumulation of oxidative stress in mitochondria, sustains mitochondrial respiration, and boosts cardiac performance both in vitro and in vivo models involving DCM.230 Paeonol has been found to promote fusion of mitochondria through Opa1 activation by activating STAT3. This evidence concerns the gene OPA1 and familial dilated cardiomyopathy.