MFN1 and breast carcinoma: Treatment with AZD5363 (Capivasertib) is believed to affect mitochondrial dynamics in BCSCs by suppressing MFN1 expression, thus increasing the sensitivity of BCSCs to doxorubicin chemotherapy.249 Furthermore, Transferred breast carcinoma cells have been found to spread to organs that display a more favorable microenvironment characterized by elevated mitochondrial division mediated by Drp1 and mitochondrial elongation factor (MIEF)1/2.