Compared with Mkp1fl/fl mice, MKP1-LKO mice were resistant to the development of hepatic steatosis when fed either a CSAA or CDAA diet as shown by markedly reduced macrovesicular steatosis (Fig. 1d), microvesicular steatosis (Supplemental Fig. 2j), hepatocyte ballooning (Fig. 1e) and lobular inflammation (Fig. 1f). The gene discussed is DUSP1; the disease is Hepatic steatosis.