Since MKP1 is upregulated in CDAA diet fed mice it implies that the CDAA diet evokes fibrosis in a manner that correlates with the upregulation of MKP1 and hepatocellular death rather than just hepatic steatosis, consistent with the notion that multiple “hits” are required for the development of NASH. The gene discussed is DUSP1; the disease is metabolic dysfunction-associated steatohepatitis.