Dysregulation of redox balance as a result of unbridled lipid accumulation as seen in NASH fed animals leads to lipotoxic stress and the generation of H2O237,50,67 which induces MKP1 expression and causes local nuclear dephosphorylation of p38 MAPK and JNK. Here, MAPK8 is linked to metabolic dysfunction-associated steatohepatitis.