DUSP1 and metabolic dysfunction-associated steatohepatitis: We found that DUSP1 mRNA levels in core liver biopsies were significantly elevated by ~2-fold in obese steatotic (BMI; 36–61, NAS = 1–2) and obese NASH (BMI; 36–61; NAS > 5, fibrosis score = 1–2) patients as compared with obese non-steatotic (BMI; 36–61, NAS = 0) patients (Fig. 1a).