Compared with Mkp1fl/fl mice, MKP1-LKO mice were resistant to the development of hepatic steatosis when fed either a CSAA or CDAA diet as shown by markedly reduced macrovesicular steatosis (Fig. 1d), microvesicular steatosis (Supplemental Fig. 2j), hepatocyte ballooning (Fig. 1e) and lobular inflammation (Fig. 1f). This evidence concerns the gene DUSP1 and fatty liver disease.