DUSP1 and steatosis: Compared with Mkp1fl/fl mice, MKP1-LKO mice were resistant to the development of hepatic steatosis when fed either a CSAA or CDAA diet as shown by markedly reduced macrovesicular steatosis (Fig. 1d), microvesicular steatosis (Supplemental Fig. 2j), hepatocyte ballooning (Fig. 1e) and lobular inflammation (Fig. 1f).