However, the infection does have a transcription reprogramming effect on other genes, with the DEG analysis between naïve and 14 dpi mature N4 neutrophils revealing changes in cellular responses to interferons (IFNs), such as the upregulation of Stat1. In addition, T. brucei induces upregulation of Irf7 and Ifit3, involved in type I interferon (IFN)-mediated inflammation, as well as Ifi204, Ifi47, Isg15, Ifitm3, Igtp, and Gbp7, known to mediate IFN-γ responses (Fig. 2f, Supplementary Table s4). The gene discussed is ISG15; the disease is infection.