For example, promoter or enhancer peaks at TTR, SMIM6, and SPRY1 loci all contain HNF1A motifs and lose accessibility along the T2D trajectory (Fig. 6d, Supplementary Fig. 5a–b); all three are downregulated in T2D and show intra-donor heterogeneity. The gene discussed is ERLN; the disease is type 2 diabetes mellitus.