There is evidence that esophageal cancers have higher levels of H3K27Ac in the CCAT1 promoter region, which may explain the increased expression of CCAT1 [53], and the increased H3K27 acetylation level in the GHET1 promoter region in liver cancer may be the cause of the increased GHET1 expression [54]. The gene discussed is GHET1; the disease is liver cancer.