The univariable Cox proportional risk regression analysis showed that tumor differentiation, stage, lymphatic metastasis, CEA level, AZGP1 level and diabetes were the factors influencing the OS of ICC patients after surgery; (p < 0.05); tumor differentiation, staging, lymphatic metastasis, CEA level, AZGP1 level, CA19-9 level and diabetes mellitus were the factors influencing postoperative RFS in ICC patients (p < 0.05) (Table 2). The gene discussed is AZGP1; the disease is Lymphatic Metastasis.