PIN1 and fetal growth restriction: Importantly, cis-P-tau accumulation and protein aggregates in the placenta due to Pin1 inhibition were also accompanied with the PE-like pathological and clinical features, including fetal growth restriction (Supplementary Fig. 11d), proteinuria (Supplementary Fig. 11e), increased sFlt-1 and sEng production (Supplementary Fig. 11f, g).