In addition, hematopoietic and lymphoid cells, such as myeloma, lymphoma, and leukemia cell lines, showed high levels of apoptosis-related signaling including the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TWEAK cytokine (Fig. 6a), suggestive of a particular role of the TRAIL signaling and TWEAK cytokine in blood cancer. Here, TNFSF10 is linked to plasma cell myeloma.