Furthermore, the growth of colon cancer cells was suppressed in vivo.576 Catapano’s group later demonstrated that a promoter-targeted siRNA, compound (243), could inhibit transcription of the c-Myc gene, leading to growth arrest and cell senescence of human PC3 cells.577 In 2013, Teng’s group designed and synthesized a c-Myc-siRNA, compound (244), and transfected it into SKOV3 ovarian carcinoma cell lines, demonstrating its potential in cancer therapy. Here, MYC is linked to malignant colon neoplasm.