PDE6D and familial pancreatic carcinoma: Ultimately, both compound (125) and compound (126) effectively inhibited KRAS-PDEδ PPI, disrupted the correct localization of KRAS on the cell membrane, down-regulated the phosphorylation of key proteins Erk and Akt in the downstream pathway of KRAS, and induced apoptosis in KRAS-mutated pancreatic cancer cell lines.353