In 2021, Alexander et al. discovered curcumin interferes with the fundamental function of Myc and induces cross-linking between this oncogenic TF and its co-activator, TRRAP.431 Covalent cross-linking of TRRAP with Myc can permanently isolate TRRAP, resulting in interference in the binding balance between TRRAP and its tumor suppressor partners. This evidence concerns the gene MYC and neoplasm.