TP53 and neoplasm: Furthermore, in vivo pharmacodynamic experiments of DS-3032 on SH-SY5Y xenograft nude mice have demonstrated that DS-3032 activated the TP53 signaling pathway in transplanted tumor tissue, inhibited tumor growth, and prolonged the survival of mice.392 In addition, DS-3032 treatment has been found to increase apoptotic cells and decrease proliferative cells.