TP53 and neoplasm: In wild-type p53 cells, NVP-CGM097 significantly induced the redistribution of p53 into the nucleus (IC50 = 0.224 μM).388 In a mouse model of human cancer, NVP-CGM097 exhibits favorable pharmacokinetic characteristics and impacted pharmacodynamic markers in human tumors, leading to tumor regression at well-tolerated dose levels.