MYC and cancer: The interaction between Myc and TRRAP takes place in a precise region of the Myc protein called MB-II, which is also at the core of the Myc transactivation domain (TAD).431 Despite the disordered nature of the Myc TAD, evidence suggests that MB-II becomes a well-defined structure when it interacts with TRRAP, providing an opportunity to develop inhibitors that can block Myc-TRRAP interactions and specifically target Myc-driven cancers.432–434