Bcl-2 family plays a crucial role in the endogenous apoptosis signal transduction pathway by regulating the mitochondrial/cytochrome C-mediated apoptosis process.356,357 This family consists of anti-apoptotic and pro-apoptotic proteins that act synergistically as apoptotic switches, ultimately determining the cell’s fate.358–360 Among them, Bcl-2 is an anti-apoptotic protein that is highly expressed in various hematological malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), making it an attractive drug target. This evidence concerns the gene BCL2 and mantle cell lymphoma.