Notable TFs include p53, Myc, estrogen receptor (ER), androgen receptor (AR), which are involved in the pathological process of neoplasm, X-box-binding protein 1 (XBP1), nuclear factor erythroid 2-related factor (NRF2) in age-related diseases and neurodegenerative diseases, and NF-κB, BTB, CNC homology (BACH), EB, E3 in immunological diseases. Here, ESR1 is linked to neurodegenerative disease.