Both types of synthesized siRNAs were effective in reducing c-Myc mRNA levels in KB-3-1 human epidermoid carcinoma cells, leading to inhibition of cell proliferation.575 In 2009, Ge’s group obtained a c-Myc siRNA, compound (242), through in vitro transcription and transfected it into HT-29 cells. This evidence concerns the gene MYC and squamous cell carcinoma.