EGFR and non-small cell lung carcinoma: YK-029A (63), an oral, irreversible third-generation EGFR TKI, is another osimertinib analog developed by Hainan Yuekang Biopharmaceutical Co Ltd. The drug is intended to treat advanced NSCLC with drug resistance and disease progression acquired by T790M gene mutation after previous treatment of EGFR TKIs.