TP53 and cancer: It can activate nearby or distant genes in response to an enhancer, while also indirectly inhibiting the transcription of numerous genes.209–213 P53 can be categorized as mutant type or wild type, with mutant p53 promoting tumorigenesis and wild-type p53 having broad-spectrum tumor inhibition.206–208 TP53 mutations typically reduce the expression of p53 protein or produce inactive variants, thus compromising its cancer-inhibiting properties.