The presence of cholesterol in COVID-19 plasma patients is increased through SREBP2 activation (Lee et al, 2019), whereas the accumulation of triglycerides is associated with the activation of SREBP1 (Yuan et al, 2019), which has already been observed in cells infected with SARS-CoV-2 (Dias et al, 2020). This evidence concerns the gene SREBF2 and COVID-19.