Inflammasome activation may occur through the recognition of cholesterol crystals (Rajamäki et al, 2010), which presents a close relationship with LDs (Ioannou et al, 2017, 2019) and can represent an important link between cholesterol metabolism and inflammation in COVID-19 pathogenesis, but direct effects of SREBP2-SCAP on inflammasome assembly have been proposed (Guo et al, 2018). Here, SREBF2 is linked to COVID-19.