TP53 and lung cancer: Cluster3-related gene modules are significantly enriched in the PI3K−Akt signaling pathway, Cluster4-associated gene modules are significantly enriched in the p53 signaling pathway and FoxO signaling pathway, Cluster6-related gene modules are significantly enriched in Pentose phosphate pathway and chemical carcinogenesis-reactive oxygen species, which are associated with lung cancer(Fig 8d and 8e).