IL1B and infection: Analysis of chemokines revealed that, in comparison to infection with WT Mtb or Mtb sucT::Tn comp, secretion of IP-10, CXCL2, GROA (GRO-alpha) and RANTES were significantly increased with the sucT mutant, as was the secretion of key pro-inflammatory cytokines (TNFα, IL-6, IL1-β and IL-22), indicative of macrophages poised for increased proinflammatory state [Fig 3B].