Several HLA-mediated B cell–T cell interactions were predicted in MF samples, likely associated with antigen presentation, while other interactions, such as CD70-CD27, ICAM3-ITGAL, ICAM3-ITGB2, and TNF-TNFRSF1B, could mediate T cell activation, adhesion, and anti-apoptotic signals. Here, TNFRSF1B is linked to mycosis fungoides.