In ECs, cell-to-cell adhesion with malignant cells was predicted via lamins, collagens, and matrix glycoproteins in most MF samples, while clonal malignant cells mediated several pro-angiogenic interactions by TGFB1, VEGFA, NAMPT, EFNB2, and other factors according to the patient sample. The gene discussed is EFNB2; the disease is mycosis fungoides.