In view of their markedly increased numbers in the cutaneous MF TME, we focused on further characterizing the myeloid cells, including macrophages (AIF1, CD68, ISG15, C1QC) and dendritic cells (DCs) (CD1C, CLEC9A, LAMP3, LILRA4) (Figure 2A). This evidence concerns the gene ISG15 and mycosis fungoides.