TNC and Alzheimer disease: Comparison of the MF and AD/PS fibroblast data sets showed MF differential expression of multiple genes associated with wound healing and fibrosis, including collagens, TNC, LOXL, and MMP enzymes, and signaling through various cytokines and growth factors such as IL-6, IL-8, IL-13, IL-17, IFN, and PDGF (Figure 5 and Figure 7F).