The second MF-specific macrophage subset (APOE+ TAMs) identified M2-like TAMs (49), upregulating MRC1, CSF1R, CD81, chemokines, matrix remodeling, cathepsins, complement, eicosanoid, and apolipoprotein genes, all contributing to promote immunosuppression, tumor cell extravasation, migration, survival, and proliferation (50–52). Here, CD81 is linked to neoplasm.