The second MF-specific macrophage subset (APOE+ TAMs) identified M2-like TAMs (49), upregulating MRC1, CSF1R, CD81, chemokines, matrix remodeling, cathepsins, complement, eicosanoid, and apolipoprotein genes, all contributing to promote immunosuppression, tumor cell extravasation, migration, survival, and proliferation (50–52). This evidence concerns the gene APOE and neoplasm.