IL12-MSA led to a decrease in the proportion of TCF-1–expressing, SIY-reactive CD8+ T cells and a concomitant increase in the proportion of TIM-3–expressing, SIY-reactive CD8+ T cells in the TdLNs of KP.SIY flank tumor–bearing mice (Figure 1F), indicating that IL12-MSA leads to the expansion of effector-like CD8+ T cells. The gene discussed is TPO; the disease is neoplasm.