IL12-MSA upregulated CD25 expression in TdLNs, spleens, and tumors of KP.SIY flank tumor–bearing mice and spleens of KP.SIY lung tumor–bearing mice (Figure 1D), while GzmB levels were only increased in the TdLNs of KP.SIY flank tumor–bearing mice (Figure 1E). This evidence concerns the gene TPO and neoplasm.