Consistent with reduced Il12rb1 and Il12rb2 expression by primed, SIY-reactive CD8+ T cells in lung TdLNs (8), SIY-reactive CD8+ T cells from KP.SIY lung tumor–bearing mice bound significantly less IL12-MSA than SIY-reactive CD8+ T cells from flank tumor–bearing mice (Figure 2, A and B). Here, IL12RB2 is linked to neoplasm.