In addition, our data represented that Salmonella typhimurium decreased the expression of jejunal ZO-1, occludins, and claudins-4, but the mRNA expression of all three was significantly increased (P < 0.05) when pretreated the mice with L. buchneri GX0328-6 before infection with Salmonella typhimurium (Fig. 6). Here, CLDN4 is linked to infection.