Allicin has been reported to activate nuclear translocation of Nrf2 in colon cancer studies [50], we found that allicin promoted the nuclear translocation of Nrf2 for the first time in S-AKI, however, the specific mechanism for regulation of Nrf2 by allicin has not been clearly reported. The gene discussed is NFE2L2; the disease is malignant colon neoplasm.