BCL2 and Familial prostate cancer: For instance, AgNPs synthesized using extracts of Salvia miltiorrhiza [145], Pinus roxburghii [145], Alternanthera sessilis [146], Dimocarpus Longan Lour [147], Elderberry and Acai berry [148], Azadirachta indica [149], etc. Most studies on prostate cancer cell lines using green synthesized AgNPs, suggest that the nanoparticles cause cell toxicity, ROS generation, and apoptosis by modulating proteins including PARP-1, Bcl2, Bclxl, Bax and Caspase 3 in prostate cancer cell lines [144, 145].