And the Asian Pacific Association for the Study of the Liver (APASL) treatment option is closer to the EASL guidelines and recommends treatment of HBeAg-positive adolescents and children with HBV DNA concentrations >20 000 IU/mL and ALT levels more than twice the upper limit of normal for more than 12 months, and HBeAg-negative hepatitis with ALT levels more than twice the upper limit of normal for HBV DNA >2000 IU/mL [14]. The gene discussed is GPT; the disease is Hepatitis.