PIK3R1 and cancer: The overlapping genes included five known cancer driver genes (including HGF, MET, and PIK3R1) (Figure 2D, Figure 2—figure supplement 1C and E) and five putative FOXP2 targets (Figure 2—figure supplement 1E), such as MET and PIK3R1, identified by chromatin immunoprecipitation assays in both mice and humans (Spiteri et al., 2007; Xu et al., 2022; Mukamel et al., 2011; Vernes et al., 2011; Vernes et al., 2007).