MMP2 and myocardial infarction: MMP2 and MMP9 deficiency in vivo protects against cardiac rupture and improves left ventricular enlargement, fibrosis, and dysfunction post‐MI;[23, 36] our findings are consistent with previous results.[23, 25, 36] Furthermore, we built a Transwell invasion system in vitro that mimics the ECM in vivo.