CXCL8 and chronic obstructive pulmonary disease: NKRF is constitutively expressed in all tested human tissues; this implies a possible role of NKRF in the pathophysiology of human diseases.[11a] NKRF expression is reduced in PBMCs of patients with stable chronic obstructive pulmonary disease, and decreased NKRF expression potentially increases chronic systemic inflammation by promoting IL‐8 transcription.[12] This study also found decreased NKRF expression in pathological fibrosis myocardium.