These mice preferentially utilize lipids relative to carbohydrates during periods of rest/fasting, display mild hypoglycemia during fasting, are resistant to diabetes despite significantly elevated adiposity, and have a greater response to exogenous insulin (Icyuz et al., 2020; Liu et al., 2004; Longo et al., 2010; Sun et al., 2013; Westbrook et al., 2009). Here, INS is linked to Hypoglycemia.