EZH2 and neoplasm: In vitro: immunoprecipitation sequencing; Cleavage Under Targets & Release Using Nuclease;co-immunoprecipitation; RNA-seq;Luciferase Reporter Assay; isothermal titration calorimetry;EZH2 methyltransferase assay; ubiquitination assayIn vivo: Swiss albino mice (pharmacokinetics, complete blood counting)NOD-SCID mice (patient-derived xenograft (PDX) models (intra-tumour/intra-plasma drug concentration analysis)