As cellular senescence is involved in metabolic disorders such as NAFLD (Farrell & Larter, 2006; Meijnikman et al., 2021; Papatheodoridi et al., 2020; Schafer et al., 2017) and as these disorders lead to signs of accelerated aging, we wondered whether the loss of Pla2r1 could impact cellular senescence, glucose regulation, and liver alterations caused by Western diets (WD). Here, PLA2R1 is linked to metabolic dysfunction-associated steatotic liver disease.