In line with these results and a deleterious effect of Pla2r1, it was shown to promote features of progeroid syndromes (Griveau et al., 2018), marks of chronic obstructive pulmonary diseases (COPD; Beaulieu et al., 2021) and to increase sensitivity to endotoxic shock (Hanasaki et al., 1997). Here, PLA2R1 is linked to progeroid syndrome.