PLA2R1 and Insulin resistance: Old Pla2r1‐deficient mice (21 months) and their WT controls were analyzed for several features of aging, such as immunosenescence, defined as aging of the immune system, systemic glucose intolerance, and insulin resistance (Chang & Halter, 2011), telomere shortening (Bernadotte et al., 2016) and liver alterations (Kim et al., 2015).