PLA2R1 and fatty liver disease: In our study, the loss of Pla2r1 was associated with decreased levels of senescence marks and a better ability to regulate glucose metabolism, as well as a reduction in liver steatosis and fibrosis, which is consistent with the fact that senescent cell accumulation can promote these alterations (Ogrodnik et al., 2017; Ogrodnik & Jurk, 2017).