As Pla2r1 was herein expressed by HSCs and not hepatocytes according to scRNA‐seq, as Pla2r1 KO display decreased PLAUR levels during WD, we can speculate that liver phenotypes observed in Pla2r1 KO mice rely at least in part on decreased cellular senescence of HSCs and their paracrine function including on hepatocytes. The gene discussed is PLAUR; the disease is Wilson disease.