Nevertheless, in some cases, Pla2r1 exerts beneficial effects as its deletion increases inflammation and allergic sensitization in an asthma model (Nolin et al., 2016), decreases survival rate due to the increase in cardiac rupture after myocardial infarction (Mishina et al., 2014), and decreases tumor initiation during aging (Huna et al., 2021) or after carcinogenic treatment (Vindrieux et al., 2013). Here, PLA2R1 is linked to asthma.