Transcriptomic analysis performed on the liver revealed that dysregulation of gene expression between WD and control Chow diet (CD) in WT mice were less impacted in the liver of Pla2r1 KO mice (Figures 2e and S2A–D) in particular 78% of the genes that were significantly downregulated in Pla2r1 KO WD versus WT WD were increased by the WD regimen in WT (Figure S2E), suggesting that the loss of Pla2r1 attenuated the response to WD. Here, PLA2R1 is linked to Wilson disease.