A recent single‐cell RNA‐sequencing study24 showed that a newly defined ApoB‐Reactive CD4+T‐Regulatory Cells involve in an initially protective autoimmune response against ApoB in atherosclerosis and eventually plaque T cells that expand during progression of atherosclerosis showed a mixed TH1‐/TH17 phenotype in scRNAseq. This evidence concerns the gene APOB and atherosclerosis.