PRPS1 and microsporidiosis: A recent study has identified ZIP‐1 as the first transcription factor that activates the IPR, and the first transcription factor shown to promote defense against the Orsay virus and microsporidia infection in C. elegans (Figure 4).[35] ZIP‐1 acts as a central hub for all known IPR triggers and is required for the upregulation of a subset of IPR genes.