In severe COVID‐19, the contribution of T2AE cells to circulating CRTAC1 likely is impacted by loss of the cells per se (Chait et al., 2022; Delorey et al., 2021) and remodeling of the lung epithelial compartment dominated by de‐differentiation of T2AE cells with partial loss of CRTAC1 expression (Delorey et al., 2021; Melms et al., 2021). The gene discussed is CRTAC1; the disease is COVID-19.