Similar as that found in the Stockholm cohort, MK and DDC were the most changed proteins in PD compared to controls, and significant changes were also observed for SMAD5, C–C motif chemokine 17 (CCL17), tissue factor pathway inhibitor 2 (TFPI-2), and tissue factor (TF) with similar trends of difference (Fig. 1g). The gene discussed is SMAD5; the disease is Parkinson disease.