CTRP6-mediated adipogenesis involves in the inhibition of adipocyte differentiation after CTRP6 overexpression and the restoration after CTRP6 ablation in a PPAR-γ-dependent manner, indicating the possible protective effects of CTRP6 on obesity and diabetes, although CTRP6 depletion is not cardiac specific. Here, C1QTNF6 is linked to obesity due to melanocortin 4 receptor deficiency.