In this experiment, T2DM rats showed increased serum lipid profiles, involving DEPs ApoA1, ApoA4, ApoC1 and ApoC2, participating in cholesterol metabolism, fat digestion and absorption, and vitamin digestion and absorption signaling pathways, also the results of GO enrichment analysis were all correlated with lipid metabolism. The gene discussed is APOA4; the disease is type 2 diabetes mellitus.