As the initiation of colorectal adenoma and cancer is highly correlated with Wnt hyperactivation while Wnt3a is essential for the maintenance of normal epithelium [24], we were enlightened by the culture methods by van der Wetering et al. who enriched CRC organoids by withdrawing Wnt3a in the culture media [25]. The gene discussed is WNT3A; the disease is colorectal adenoma.