Several IPF treatment-related DMGs have been identified, including Shc1, Gabra5, Nectin3, Irs2, Ppp1r3d, Shh, Bmp4, Cd14, Epha7, Cdh2, Adcyap1r1, Foxa2, Sema5a, Nup98, Dapk1, and Prdm6. Previous studies have focused on specific genes but not on regulatory networks. The gene discussed is IRS2; the disease is idiopathic pulmonary fibrosis.