Several IPF treatment-related DMGs have been identified, including Shc1, Gabra5, Nectin3, Irs2, Ppp1r3d, Shh, Bmp4, Cd14, Epha7, Cdh2, Adcyap1r1, Foxa2, Sema5a, Nup98, Dapk1, and Prdm6. Previous studies have focused on specific genes but not on regulatory networks. This evidence concerns the gene SHH and idiopathic pulmonary fibrosis.