Jason J. found unfavorable local tumor response was linked to overexpression of the DNase III (TREX1) exonuclease [33].RT acts as an inducer of antitumor immune responses, in part, depending on the type I IFN secretion caused by activation of the cGAS/STING signaling pathway and the interaction between immune cells. The gene discussed is TREX1; the disease is neoplasm.