When the cGAS-STING signaling pathway in tumor cells is activated, it induces expression of cytokines such as IL-6, TNF, and type I IFN, leading to tumor cell death or apoptosis, releases dsDNA, and other tumor-derived antigens, activates dendritic cells (DCs), and then initiates anti-tumor immunity. The gene discussed is CGAS; the disease is neoplasm.