STING1 and neoplasm: Julie M showed that irradiated mouse breast cancer cells (RT-TEX) create tumor-derived exosomes (TEX) that transmit dsDNA to DCs and cause them to upregulate costimulatory molecules and STING-dependent IFN-I activation [35].Therefore, exploring the molecular mechanisms affecting the activation of this pathway will provide new targets for enhancing RT-induced anti-tumor immunity.(Fig. 2).