However, whether radiotherapy can induce cGAS-STING mediated anti-tumor effect is related to the applied radiation dose, too high dose will affect the survival of immune cells in the tumor microenvironment, but also up-regulate the negative regulators of the DNA sensing pathway, inhibit cGAS-STING pathway activation, and then promote immunosuppression, while lower dose can effectively activate the cGAS/STING pathway. The gene discussed is CGAS; the disease is neoplasm.