PAR1CAR-T cells secrete proinflammatory cytokines and chemokines, including TNF-α, IFN-γ, IL-1α, IL-4, IL-6, IL-17A, and GRO, upon encountering PAR1 antigens that exhibit potent cytolytic capacities against PAR1-expressing tumor cells. The gene discussed is CXCL1; the disease is neoplasm.