BDNF and neurodegenerative disease: In studies on mice, it was shown that BOHBUT promoted hippocampal brain-derived neurotrophic factor (BDNF) expression (4, 5), a protein which is positively associated with neuronal survival, neurotransmitter regulation, synaptic plasticity, and memory formation whereas a decrease in BDNF is linked to increased risk of neurodegenerative diseases [13, 14].