OXCT1 and Alzheimer disease: Accounting for the remaining residual correlation, cis-MR suggested little evidence of therapeutic modulation of OXCT1 on either cognitive performance (βIVW = 0.038, PIVW = 0.312) or AD (βIVW =  − 0.331, PIVW = 0.290) while the direction of effect estimates was consistent with those previously shown (Additional file 1: Table S17).