For instance, lncRNA FGD5-AS1 is downregulated in periodontitis gingival tissues and human periodontal ligament cells in an inflammation model, and it can negatively regulate the expression of inflammatory factors such as TNF-α and IL-1β through the miR-142-3P/SOCS6/NF-κB signaling pathway [53]. This evidence concerns the gene TNF and periodontitis.