We identified 20 significantly dysregulated necroptosis-related lncRNAs that distinguish periodontitis from healthy samples, with 10 of them selected to compose a molecular classifier for periodontitis, including EPB41L4A-AS1, FAM30A, LINC01004, MALAT1, MIAT, OSER1-DT, PCOLCE-AS1, RNF144A-AS1, CARMN, and LINC00582. Here, KMT2E-AS1 is linked to periodontitis.