Several studies examining the correlation between RA and HMGB1 or TLRs have demonstrated that HMGB1 and TLRs play an indispensable role in the progression of RA as pro-inflammatory cytokines (Kokkola et al. 2002; Taniguchi et al. 2003; Elshabrawy et al. 2017). The gene discussed is HMGB1; the disease is rheumatoid arthritis.