To identify the contribution of cGAS-STING signalling to the TET2-medicated inhibition of lung cancer cell proliferation, migration and invasion, we then treated the vector control and TET2-overexpressing A549 and H1975 cell lines with the cGAS-STING signalling inhibitor RU.521 (10 μM). The gene discussed is TET2; the disease is lung carcinoma.