After applying regression between controls and AD subjects separately, we observed that the relationship between HGS and CASP-12 was nearly unchanged for controls (1-point increase in HGS lead to a 0.0809 increase in CASP-12) and AD subjects (1-point increase in HGS lead to 0.0793 increase in CASP-12). Here, CASP12 is linked to Alzheimer disease.