INS and hydrops fetalis: Therefore, in this work, we employed db/db mice and established the high-fat-diet (HFD) / streptozotocin (STZ) -induced diabetic (HF-diabetic) mice and high-glucose-damaged (HGD) neuron cell model to evaluate the definitely therapeutic effects of Ex-4, and explored the underlying mechanisms which may closely related with DE, bran-derived insulin and Wnt/β-catenin signaling pathway.