These data point towards a relevant role for SAMHD1 in cell proliferation and BC development as previously suggested [44], albeit contrarywise to existing evidences derived mainly from the study of hematological cancers where it was assumed that SAMHD1 depletion led to an increase in dNTP availability, thereby favoring cell proliferation [39, 40]. This evidence concerns the gene SAMHD1 and hematopoietic and lymphoid cell neoplasm.