Single-cell multi-omics allowed us to derive a 44-gene ‘p53LSC-signature’ (Supplementary Table 4) by comparing gene expression of HD, JAK2-mutant MF HSPC and TP53 WT pre-LSC to transcriptionally defined TP53-mutant LSCs (Fig. 2a,k). The gene discussed is TP53; the disease is Huntington disease.