Mice developed leukemia in 27–31 weeks with high numbers of human CD34+ myeloid blast cells in the bone marrow (BM; Extended Data Fig. 3b–d), with a progenitor phenotype, TP53 mutations and CNAs similar to the dominant clone from patients’ primary cells (Fig. 1i and Extended Data Fig. 3e–l). The gene discussed is CD34; the disease is leukemia.