DNMT1 and central nervous system cancer: The well-established functions of CAHM, which is also known as colorectal adenocarcinoma hypermethylated, as a prognostic biomarker in colorectal and thyroid carcinoma54,55, and its regulation by DNMT1 in glioma cells, suggest its involvement in glioma grade, subtype, malignant behavior, and prognosis56.