Our analysis revealed that the expression of most genes, including DNMT3B, NOP2, DNMT1, ALYREF, NSUN2, NSUN5, TET2, TET3, DNMT3A, TET1, and YBX1 were significantly higher in ESCC tissues than in normal adjacent tissues (Fig. 1A). This evidence concerns the gene TET3 and esophageal squamous cell carcinoma.