The well-established functions of CAHM, which is also known as colorectal adenocarcinoma hypermethylated, as a prognostic biomarker in colorectal and thyroid carcinoma54,55, and its regulation by DNMT1 in glioma cells, suggest its involvement in glioma grade, subtype, malignant behavior, and prognosis56. Here, CAHM is linked to central nervous system cancer.