While no association of baseline ApoE present in non-HDL or HDL particles was detected with incident dementia, lower ApoE level was significantly associated with higher ADAS-cog scores only in HDL (β = 0.20; 95% CI: 0.10 to 0.30) [21], as we also observed in this study in whole plasma in the total GEM sample of 3031 subjects. This evidence concerns the gene APOE and dementia.