Using differential gene expression analysis in TCGA-HCC cohort, a heatmap illustrated that a total of 18 PANRGs (AIM2, PYCARD, CASP3, CASP8, RIPK1, FADD, GSDME, SCAF11, NR2C2, GSDMD, NLRP3, ADAR, IL1B, IRF8, CASP4, NLRP12, CASP6, PARP1) were differentially expressed between HCC and normal liver tissues (Fig. 2A). The gene discussed is CASP4; the disease is hepatocellular carcinoma.