Using differential gene expression analysis in TCGA-HCC cohort, a heatmap illustrated that a total of 18 PANRGs (AIM2, PYCARD, CASP3, CASP8, RIPK1, FADD, GSDME, SCAF11, NR2C2, GSDMD, NLRP3, ADAR, IL1B, IRF8, CASP4, NLRP12, CASP6, PARP1) were differentially expressed between HCC and normal liver tissues (Fig. 2A). This evidence concerns the gene RIPK1 and hepatocellular carcinoma.