We found a significant association between SOST levels and NFL, GFAP, phosphorylated versions of the tau protein (p-tau181 and p-tau231) and Aβ40, while no significant association was found between SOST levels and other AD-related biomarkers (Table 3, unadjusted correlations are shown in Supplementary Fig. 1). This evidence concerns the gene GFAP and Alzheimer disease.