APOE and Alzheimer disease: Plasma SOST levels were significantly higher in the Aβ+ group (71.49 ± 25 pmol/L) compared with the Aβ− group (56.51 ± 22.14 pmol/L), before and after adjusting for potential AD risk factors including age, sex and APOE ε4 status (P < 0.003, P* = 0.008; Table 2).