For example, we found predictive value of chr20q amplifications in CMS2 tumours treated with FOLFIRI plus cetuximab (Fig. 5a, b), which is evident by the significant interactions of TOP1 (pint = 0.07, FDRint < 0.2) and ARFRP1 (pint = 0.01, FDRint < 0.2). Here, TOP1 is linked to neoplasm.