For example, we found predictive value of chr20q amplifications in CMS2 tumours treated with FOLFIRI plus cetuximab (Fig. 5a, b), which is evident by the significant interactions of TOP1 (pint = 0.07, FDRint < 0.2) and ARFRP1 (pint = 0.01, FDRint < 0.2). The gene discussed is ARFRP1; the disease is neoplasm.