In contrast, the similarity of left-sided tumours and CMS2 (Fig. 2f) was characterised by mutations in APC, TP53 and chr20q amplifications (SRC, TOP1, BCL2L1, ZNF217), which were all significantly enriched in both left-sided and CMS2 tumours (Fig. 2g, h; FDRmol < 0.05, hypergeometric test). Here, TOP1 is linked to neoplasm.