Subsequently, employing a similar approach, we conducted a thorough analysis of the correlation between the clinical characteristics of melanoma and remaining five model genes, i.e. IFNAR2 (Supplementary Fig. S2A–H), LBP (Supplementary Fig. S3A-C), MAPK10 (Supplementary Fig. S3D–H), RAC1 (Supplementary Fig. S4A–C), and TLR2 (Supplementary Fig. S4E–L). The gene discussed is RAC1; the disease is melanoma.