METTL3 and Alzheimer disease: Gene expression for METTL3, WTAP, RBM15, RBM15B, CBLL1, YTHDC1, YTHDF1, YTHDF3, IGFBP1, IGFBP2, IGFBP3, ELAVL1, IGF2BP1, and ALKBH5 was higher in AD cortex samples compared to non-AD controls, while expression for YTHDC2, YTHDF2, FMR1, LRPPRC, and RBMX was generally lower (Fig. 2A,B).