The genes most commonly amplified in bladder cancer include AHR, BCL2L1, CCND1, CCNE1, E2F3, EGFR, ERBB2, FGFR3, GATA3, KRAS, MDM2, MYCL1, PPARG, PVRL4, SOX4, TERT, YWHAZ, and ZNF703, whereas the most commonly deleted genes are TP53, FGFR3, KDM6A, STAG2, CDKN2A, and RAD51B [106]. The gene discussed is KDM6A; the disease is urinary bladder carcinoma.